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Alzheimer’s disease researchers extend the amyloid degradation toxicity hypothesis to the population level

Despite affecting millions worldwide, Alzheimer’s disease (AD) has long lacked effective treatments due to a fundamental inadequacy of our understanding of its etiology and pathogenesis. The absence of an integrative theory connecting the molecular origins of AD with disturbances at the organelle and cell levels, changes in relevant biomarkers, and population-level prevalence has hindered progress.