If you have ever let your mind wander, you have relied on the brain’s default mode network (DMN). Scientifically, the DMN is a connection of brain regions that interact when a person is in a state of wakeful rest. This network is important for using our short-term memory, posing the question: Do changes in the DMN play a key role in the short-term memory loss seen in the progression of Alzheimer’s disease (AD)? And is the DMN affected differently in women and men?