Alcohol use disorder (AUD) quickens the pace of Alzheimer’s disease progression when paired with genetic susceptibility. Scripps Research and University of Bologna scientists have reported in the journal eNeuro that repeated alcohol intoxication is associated with changes to gene expression indicative of disease progression in the brains of mice that are genetically predisposed to Alzheimer’s. When repeatedly exposed to intoxicating amounts of alcohol, these mice showed signs of cognitive decline approximately two months sooner than they usually would.