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Genetic changes differed, increased in people with Alzheimer’s disease

Inside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer’s disease, these errors—known as somatic mutations—may build up at a faster rate. A new study by investigators from Brigham and Women’s Hospital and Boston Children’s Hospital found that patients with Alzheimer’s disease (AD) have a greater number of somatic mutations in their brain cells and that these mutations differed from people without Alzheimer’s disease. The team’s results are published in Nature.