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Mass spectrometry to detect key markers of Alzheimer’s

A group of Skoltech scientists led by Professor Evgeny Nikolaev in collaboration with colleagues from MIPT, Engelhardt Institute of Molecular Biology of RAS, and Emanuel Institute of Biochemical Physics of RAS has overviewed how mass spectrometry techniques help to study the diversity of beta-amyloid peptides, which are among the main biomarkers of Alzheimer’s disease. Their paper summarizing recent achievements in the area was published in Mass Spectrometry Reviews and cites the researchers’ previous study, in which they found a new potential trigger for the accelerated formation of amyloid plaques in the brain, which are considered to be one of the causes of Alzheimer’s. New MS-based technologies should help to better understand the pathogenesis of the disease, diagnose it at early stages, predict risks, and create more effective therapeutic approaches.

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