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New findings for the function of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the “tau interactome” uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons. They also suggest a mechanism for how tau gets released from neurons and spreads throughout the brain, a pathological process that is strongly correlated with disease progression.