New genetic therapy shows promise for motor neuron disease and frontotemporal dementia

February 16, 2024

Macquarie University neuroscientists have developed a single-dose genetic medicine that has been proven to halt the progression of both motor neuron disease (MND) and frontotemporal dementia (FTD) in mice—and may even offer the potential to reverse some of the effects of the fatal diseases.

Chemotherapy shortage did not increase cancer patient mortality
During a shortage of the generic platinum chemotherapy drugs cisplatin and carboplatin that began in early 2023, there was no difference in mortality rates among patients with advanced cancer compared to the previous year, and prescription rates for the two drugs fell less than three percent overall—and 15.1 percent at the peak—according to an analysis published this week in the Journal of the National Cancer Institute by researchers from the University of Pennsylvania's Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.
Refrigerated raw milk harbors infectious flu virus for 5 days, study finds
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HIF1α identified as crucial for T cell activation in oxygen-poor tumors
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective. Thus, finding ways to disarm that resistance and rejuvenate anti-cancer TILs—so they can kill tumor cells—is an important goal for cancer clinicians. Yet any potential intervention has to take place under unusual conditions—the cancer microenvironment nearly devoid of oxygen due to fast growth of a tumor and the poor oxygen delivery by the abnormal tumor vasculature.
Stay sober and have a jolly holiday season with these expert tips
Last year, when Lauren Haydel began her first sober holiday season, she wondered how difficult it would be to avoid alcohol at family parties and celebrations with friends. She owns a boutique, Fleurty Girl, in New Orleans' French Quarter, a neighborhood synonymous with drinking.
A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth
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New genetic therapy shows promise for motor neuron disease and frontotemporal dementia

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