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New method identifies spatial biomarkers of Alzheimer’s disease progression in animal model

Many diseases affect how cells are spatially organized in tissues, such as in Alzheimer’s disease, where amyloid-β proteins clump together to form plaques in the brain. Studying how cells differ in various regions of tissue could help scientists better understand the key changes that lead to Alzheimer’s and other diseases. But integrating data on gene expression and cell structure and spatial location into the same analysis has proven challenging.