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People with increased genetic risk of Alzheimer’s may lose sense of smell first, research suggests

People who carry the gene variant associated with the strongest risk for Alzheimer’s disease may lose their ability to detect odors earlier than people who do not carry the gene variant, which may be an early sign of future memory and thinking problems, according to a study published in the July 26, 2023, online issue of Neurology. The gene variant associated with this increased risk of Alzheimer’s is called APOE e4.