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Perivascular cells could induce microglial malfunction associated with Alzheimer’s disease

Microglia, the primary immune cells in the central nervous system, defend humans and animals from infections by “eating” pathogens, dead cells, toxic proteins and other debris in the brain. Recent neuroscience studies have consistently highlighted the role of microglia in the development of Alzheimer’s disease (AD) and other neurodegenerative diseases, suggesting that they can sometimes start “eating” or engulfing crucial connections between neurons.