How physical activity protects the brain—cell by cell—in Alzheimer’s disease

June 12, 2025

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise.

Could links between Alzheimer's and gut health lead to prevention?
Alzheimer's disease affects more than 55 million people worldwide, and that number is projected to nearly triple by 2050. It has long been thought of as something that happens in the brain: a slow accumulation of toxic proteins, a gradual loss of neurons, a tragedy that unfolds in the mind. But a new collaborative transdisciplinary study by the University of Technology Sydney and Massachusetts General Hospital/Harvard Medical School is pointing somewhere else entirely: the gut.
In Switzerland, colorectal cancer is increasing among people under 50
While the incidence of colorectal cancer is decreasing among those over 50, it is rising at an alarming rate among younger individuals, sometimes as early as their thirties. A team from the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) has published the first national study on this phenomenon in Switzerland.
Poll: Americans see health care as a right, and seek equity
A majority of U.S. adults agrees that health care is a right, not a privilege, and that the nation should aim to eliminate health inequities for everyone, according to a new report from the Institute for Policy Solutions at the Johns Hopkins School of Nursing. Based on a survey conducted last fall, the institute's 2025 Health Inequities Survey used a national probability sample of 1,578 U.S. adults recruited from the National Opinion Research Center's AmeriSpeak panel, which covers approximately 97% of U.S. households, with an intentional oversample of individuals identifying as American Indian or Alaska Native.
Smart implants: How robotic micro-actuators are enhancing bone healing
Smart implants that not only stabilize a fracture but also monitor the healing process from day one—and deliver targeted support when required—are currently being developed at Saarland University by a team of engineers, medical researchers and computer scientists. The engineering team led by Professor Paul Motzki is contributing shape-memory micro-actuators with integrated sensing capabilities, while Professor Bergita Ganse and her research group provide the medical expertise in fracture healing. If a fracture is not healing as it should, these novel implants can respond mechanically at the fracture gap by adapting their stiffness or by applying controlled micro-movements to mechanically stimulate tissue and promote bone regeneration.
Smoking, vaping weed increases risk of asthma attacks among young adults, study finds
Weed might increase a young person's risk of an asthma attack, whether or not they are smoking or vaping it, a new study says. Young adults had 57% to 81% higher odds of an asthma attack if they smoked or vaped cannabis, researchers report in the journal Chest.

How physical activity protects the brain—cell by cell—in Alzheimer’s disease

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