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Researchers determine the structural basis for ApoE-Aβ interactions

Alzheimer’s disease (AD) is a debilitating incurable disease that affects millions of patients worldwide. Deposits of amyloid beta (Aβ) amyloid in the brain is key to AD pathology at early stages. Apolipoprotein E (apoE) interacts with Aβ and can influence this pathologic process. Although apoE-Aβ interactions have been extensively studied and have been proposed as a therapeutic target in AD, results of prior studies are confusing. Some report that apoE promotes Aβ amyloid formation while others report that apoE blocks this pathological process.