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A prognostic Alzheimer’s disease blood test in the symptom-free stage

Using a blood test, a German-Dutch research team has predicted the risk of Alzheimer’s disease in people who were clinically diagnosed as not having Alzheimer’s disease but who perceived themselves as cognitively impaired (Subjective Cognitive Declined, SCD). The researchers analyzed blood samples from an SCD cohort supervised at the Alzheimer Center Amsterdam. Using a test developed at Ruhr-Universität Bochum (RUB) called the Immuno-Infrared Sensor, they identified all 22 subjects at study entry who developed Alzheimer’s dementia, thus the clinical symptoms, within six years. The test also showed which subjects were at very low risk to develop Alzheimer’s dementia within six years. The team describes the results in the journal Alzheimer’s Research and Therapy, published online 24 December 2020.