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Abnormalities in neurodevelopment could lay the foundations for Alzheimer’s disease

What if Alzheimer’s disease left its mark on the embryo? Khadijeh Shabani and her colleagues from the Brain Development team led by Bassem Hassan (Inserm) at Paris Brain Institute show that the amyloid precursor protein (APP) has a specific biological role during neurodevelopment. It delays the onset of neurogenesis, i.e., the differentiation of stem cells into different nerve cell lineages.