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Amyloid plaque mutation map opens new avenues for early detection of Alzheimer’s disease

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer’s disease. The comprehensive mutation map, which is the first of its kind, has the potential to help clinical geneticists predict whether the mutations found in amyloid beta can make an individual more prone to developing Alzheimer’s disease later in life. The complete atlas of mutations will also help researchers better understand the biological mechanisms that control the onset of the disease.