Dissection of the polygenic architecture using iPSC lines derived from Alzheimer’s disease

March 4, 2022

A research team led by CiRA Professor Haruhisa Inoue has developed a cellular dissection of polygenicity (CDiP) technology, which enables the reconstruction of the clinical conditions of Alzheimer’s disease (AD) from patients’ genetic data by using iPS cells and artificial intelligence.

Combining ctDNA and genomic profiling predicts cancer relapse and treatment response
Researchers from Iwate Medical University and Tohoku University have revealed that it is possible to predict cancer relapse and treatment response by measuring circulating tumor DNA (ctDNA), in tandem with data from comprehensive genomic profiling (CGP). Their study is published in the journal Cancer Science.
Study explores how Tourette syndrome differs by sex
Tourette syndrome is currently diagnosed about three times more frequently in males than in females. A new study finds that female individuals are less likely to be diagnosed with the syndrome, take longer to receive a diagnosis and are older when they are diagnosed than male individuals. The study is published in Neurology.
Blood test discovery offers hope for easier asthma diagnosis and care
Scientists at Rutgers Health have discovered that a simple blood test could diagnose asthma and determine its severity, a breakthrough that could transform how the disease is identified and monitored.
New mechanism that shields persister tumor cells from immune system identified
Cancer therapies do not always succeed in eliminating tumor cells. Some of these cells enter a state of senescence—a latent, non-dividing state that is generally irreversible. Others, however, enter a state known as "persistence," where dormancy is temporary and reversible. This state allows the cells to begin growing again after the treatment has ended, leading to cancer recurrence.
Team links gene duplications, deletions within chromosome region to nonsyndromic bicuspid aortic valve disease
Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease, according to a new study led by UTHealth Houston researchers.

Dissection of the polygenic architecture using iPSC lines derived from Alzheimer’s disease

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