Gene-editing tools pave way for new Alzheimer’s treatments

July 17, 2023

Two new studies using CRISPR gene editing offer potential new treatments for Alzheimer’s disease.

Liquid biopsy predicts response to breast cancer immunotherapy
Immunotherapy has become a standard of care in treating high-risk, early-stage breast cancers, yet it has had limited success in shrinking tumors. New biomarkers that can improve outcomes for patients are urgently needed. Now, a study led by researchers at the Vanderbilt-Ingram Cancer Center has found that repeated blood sampling—essentially, a liquid biopsy—can assess and predict the evolving antitumor immune response to therapy.
For older adults with mild cognitive impairment, exercise can be crucial to sleep quality
Staying active is known to improve sleep, but the research findings are mixed regarding the best workout. Some studies say light walking or stretching is best, others prefer moderate-intensity workouts like jogging—and some even find that vigorous exercise such as swimming makes sleep worse.
Rural youth show higher firearm exposure, suicide risk and mental health harms
Rural youth experience higher rates of firearm exposure, handgun-carrying and associated mental health risks, according to Rutgers researchers. Their study, published in Trauma, Violence, and Abuse, has examined recent literature on rural youth firearm exposure and its association with health risk behaviors and outcomes, including violence and suicide.
Blocking a cellular inflammation process could result in effective therapy for pancreatic cancer
Scientists at The Wistar Institute and clinical researchers from ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a vulnerability in pancreatic cancer that could be targeted as a potential therapy. In a new study, published in the Proceedings of the National Academy of Sciences, they show how defective mitochondria within cells spark a process that triggers inflammation. They also show how cancer cells become so dependent on this inflammation to grow that without it, they die.
Stopping and restarting certain GLP-1s to lose weight may make the drug less effective
Inconsistent use of some GLP-1 weight-loss medications, like Ozempic and Wegovy, may significantly lessen their effectiveness, according to a new preclinical study from researchers at the Perelman School of Medicine at the University of Pennsylvania. The study, published in the Journal of Clinical Investigation Insight, showed that each time overweight mice stopped and restarted GLP-1s, they dropped less and less weight compared to their original weight-loss.

Gene-editing tools pave way for new Alzheimer’s treatments

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