Genetically modified mice hint at tau hyperphosphorylation’s early role in neurodegenerative diseases

January 17, 2025

Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting microtubules, cylindrical structures that contribute to cell motility, intracellular transport and the maintenance of a cell’s shape over time. While tau has an important neurophysiological function, when it undergoes pathological changes and accumulates in the brain, this protein has been found to contribute to some neurodegenerative diseases, broadly defined as tauopathies.

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Genetically modified mice hint at tau hyperphosphorylation’s early role in neurodegenerative diseases

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