Machine learning gives nuanced view of Alzheimer’s stages

November 23, 2022

A Cornell University-led collaboration has used machine learning to pinpoint the most accurate means and timelines for anticipating the advancement of Alzheimer’s disease in people who are either cognitively normal or experiencing mild cognitive impairment.

Analytical framework reveals key insights into time persistence in human brain networks
A new international and multidisciplinary study has unveiled a novel framework for understanding the concept of time persistence in the human brain, shedding light on its essential role in brain functioning and cognition. This research, which explores how long the brain's functional networks remain in a particular state before transitioning to another, opens new doors to our understanding of human cognition and behavior.
Chagas disease study in Paraguay supports use of rapid tests to improve access to diagnosis
Rapid tests could be used to diagnose Chagas disease in resource-limited areas, according to a study led by the Barcelona Institute for Global Health (ISGlobal). The results of this research, published in PLOS Neglected Tropical Diseases, show that the prevalence of Chagas in an indigenous community in Paraguay is six times higher than in the country's capital.
New laparoscopic imaging technique accurately maps biological tissue for minimally invasive surgery
Laparoscopy, a minimally invasive surgical technique, has become the standard of care for many procedures such as prostatectomies and appendectomies due to its benefits, including faster recovery times, reduced scarring, and lower medical costs. However, the technique faces challenges in visualization, particularly when it comes to identifying critical anatomical structures, assessing tissue perfusion, and distinguishing cancerous tissue.
Cholesterol metabolism byproduct linked to Parkinson's disease
Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson's disease in mice. Published in the journal PLOS Biology, the study shows that this metabolite is responsible for the formation of Lewy bodies and the death of dopaminergic neurons in the brain—the two major hallmarks of Parkinson's disease. Blocking its activity or preventing it from being made by the body could therefore be effective strategies for treating the disease.
Study of familial ALS in Egypt reveals that genetic variations may contribute to disease progression
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle weakness and eventually death. While significant strides have been made in understanding ALS genetics, particularly in European populations, there is a gap in knowledge regarding ALS in African populations, including Egypt.

Machine learning gives nuanced view of Alzheimer’s stages

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