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Mouse study explores Alzheimer’s link to the X chromosome

Evidence in mouse and human brain tissue reveals a mechanism that may explain the sex-based differences in Alzheimer’s disease, including why females are more vulnerable. Researchers report October 4 in the journal Cell that female brains show higher expression of an X-linked enzyme called ubiquitin-specific peptidase 11 (USP11) compared to males, resulting in greater accumulation of a protein called tau.