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New methodology to study the intricacies of amyloid plaques in Alzheimer’s disease

Researchers have now combined STED microscopy, a technology that allows superresolution visualization, and a recently created new antibody to observe the amyloidogenic aggregates characteristic of Alzheimer’s disease. The work, led by scientists from the Universitat Autònoma de Barcelona (UAB), the Karolinska Institute (KI), and the biotechnology company BioArctic, both in Sweden, has surpassed the capabilities of conventional confocal microscopy, and will allow further study of the structure and morphology of amyloid deposits and the mechanisms involved in their formation.