New methodology to study the intricacies of amyloid plaques in Alzheimer’s disease

October 11, 2023

Researchers have now combined STED microscopy, a technology that allows superresolution visualization, and a recently created new antibody to observe the amyloidogenic aggregates characteristic of Alzheimer’s disease. The work, led by scientists from the Universitat Autònoma de Barcelona (UAB), the Karolinska Institute (KI), and the biotechnology company BioArctic, both in Sweden, has surpassed the capabilities of conventional confocal microscopy, and will allow further study of the structure and morphology of amyloid deposits and the mechanisms involved in their formation.

Texas A&M students develop device to combat kidney failure in newborns
Before a baby is born, doctors hope for a safe delivery, and parents hope for a healthy child. Unfortunately, conditions such as kidney failure can only be detected after birth and require immediate treatment. These patients need peritoneal dialysis to help regulate kidney function, and although lifesaving, this treatment can lead to fluid leakage and requires a lengthy healing process.
Real-time MRI captures wrists in motion
In a proof-of-concept study published in The British Journal of Radiology, UC Davis clinicians and researchers have shown that a new, low-field 0.55T MRI (magnetic resonance imaging) system can create clear videos of moving wrists. This emerging technology could provide important insights to improve diagnoses and better understand wrist anatomy.
DOT1L gene variants associated with a new neurological disorder
A study from the laboratory of Dr. Hugo J. Bellen, a distinguished service professor at Baylor College of Medicine and a principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, has discovered that gain-of-function variants in the DOT1L gene cause a new disorder.
Deep brain stimulation induces more healthy neurons and sustained memory benefits in Rett animals
A recent study from the lab of Dr. Jianrong Tang, associate professor at Baylor College of Medicine and principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital shows that deep brain stimulation (DBS) of a specific brain region results in a significant and sustained improvement of memory in Rett mice. Moreover, they found that this treatment promotes the generation of new healthy neurons in these mice.
Calorie restriction in humans builds strong muscle and stimulates healthy aging genes: Study
Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological mechanisms may also apply to humans.

New methodology to study the intricacies of amyloid plaques in Alzheimer’s disease

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