A new study by investigators from Mass General Brigham has found that a brief, simulated task of navigating a phone menu can detect the earliest changes in daily functioning in people at risk of developing Alzheimer’s disease. Investigators found that an older adult’s performance on the test, which can be completed in a matter of minutes, was associated with the hallmarks of Alzheimer’s disease pathology, including amyloid and tau depositions in the brain. The findings, which were published in the Journal of Alzheimer’s Disease, could help inform prevention trials testing treatments for Alzheimer’s disease before pronounced symptoms of cognitive decline begin.