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Researchers reconstruct whole-brain panorama of multiple structures in Alzheimer’s diseased mice

To understand the complex pathology of Alzheimer’s disease, it is necessary to simultaneously visualize Aβ plaque with its surrounding brain structures at the subcellular level in the intact brain. However, this is rarely achieved due to technical limitations. Due to spectral overlap of the fluorophore and crossover of fluorescence emission, it is still challenging to detect more than three fluorescent labels using fluorescence imaging techniques.