Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease defined by hyperphosphorylated tau (p-tau) protein accumulating in a particular pattern in specific regions of the brain. Currently, CTE can only be diagnosed at autopsy. Like similar brain diseases, the clinical symptoms in life of people diagnosed with CTE after death can vary, and there has been robust debate as to what symptoms, if any, are caused by CTE pathology.