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Researchers study how gene expression changes in the brain in Alzheimer’s disease

Although Alzheimer’s disease is one of the most studied pathologies due to its high prevalence, the molecular changes that cause astrocytes, a type of brain cell, to become reactive astrocytes, manifesting a very pronounced morphological change in response to a stressful situation, are still unknown. Neither is it known why neurons in diseased brains have difficulty communicating with each other or with the astrocytes themselves.