In a study recently published in Alzheimer’s & Dementia, researchers at Karolinska Institutet and Shandong Provincial University have reported the polygenic risk scores (PRS) with and without apolipoprotein E (APOE) gene that were associated both cross-sectionally and longitudinally with around double risk of Alzheimer’s disease. Moreover, the PRS, in combination with age, sex, and education, showed good discriminative and predictive accuracies for Alzheimer’s disease.