More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as “lipoid granules,” along with the buildup of amyloid‐beta (amyloid) plaques and tau protein tangles. These observations led to the identification of Alzheimer’s disease and related dementias. Since then, most Alzheimer’s research has focused on amyloid and tau, while brain lipid abnormalities have received far less attention.