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Nanoparticles help untangle Alzheimer’s disease amyloid beta plaques

Scientists are still a long way from being able to treat Alzheimer’s Disease, in part because the protein aggregates that can become brain plaques, a hallmark of the disease, are hard to study. The plaques are caused by the amyloid beta protein, which gets misshapen and tangled in the brain. To study these protein aggregates in tissue samples, researchers often have to use techniques that can further disrupt them, making it difficult to figure out what’s going on. But new research by Vrinda Sant, a graduate student, and Madhura Som, a recent Ph.D. graduate, in the lab of Ratnesh Lal at the University of California, San Diego, provides a new technique for studying amyloid beta and could be useful in future Alzheimer’s treatments. Sant and her colleagues will present their research on Friday, February 26 at the 65th Annual Meeting of the Biophysical Society.